Seizure control is necessary but has to be weighed against the side effects of the drugs.. -, Parasitol Res. Already have a myVCA account? The most prominent clinical sign is diarrhea in several animals. Triazine antiprotozoals (diclazuril and toltrazuril) have been used orally in catteries and kennels, especially shelter premises, but as an extralabel use. Chlorine disinfectants are effective (test check to see if too corrosive to surfaces). and transmitted securely. It is important to follow your veterinarians instructions carefully to ensure the safety and effectiveness of the treatment. Toltrazuril is also used to treat Eimeria spp., a type of protozoan parasite that infects the intestinal tract of dogs and can cause severe illness. Infective oocysts can survive for many months in the environment and are resistant to most commonly used disinfectants. Phenobarbital treatment should not be stopped suddenly. Natural Cystoisospora infections were regularly found during the 3rd or 4th week of age in dog breeding facilities although not always associated with diarrhoea. In cats with I felis, lesions usually occur in the small intestine and cecum but are minimal. TOLTRAZURIL 2.5% is the most effective, non-invasive treatment for Coccidiosis on the market in as few as 1-2 doses. Parasite control in Canadian companion animal shelters and a cost-comparison of anthelmintics. Top Companion Anim Med. Publication types Research Support, Non-U.S. Gov't MeSH terms Administration, Oral Animals Coccidiostats / administration & dosage Coccidiostats / adverse effects* Copyright 2023 Merck & Co., Inc., Rahway, NJ, USA and its affiliates. They are licensed in the US, but they are not licensed in many countries. December 28, 2022 A second 3-month oral toxicity study was conducted in dogs treated with toltrazuril at doses of 0, 1.5, 4.5 and 13.5 mg/kg bw/day. 2011 Aug;109 Suppl 1:S9-20. 2008 Feb 14;151(2-4):181-90 Toltrazuril is effective in treating coccidiosis because it prevents the sporozoites from multiplying in the intestinal mucosa. In this article, we will look at how toltrazuril works, how to administer it, and what are the potential side effects. Amprolium, although not approved, is used for puppies as a drench often adding flavors to help disguise the taste. Hammondia oocysts are indistinguishable from those of Toxoplasma and Besnoitia but are nonpathogenic in either host ( see also Besnoitiosis Besnoitiosis , Sarcocystosis Sarcocystosis , and Toxoplasmosis Toxoplasmosis .). 2010 Aug;25(3):133-5. doi: 10.1053/j.tcam.2010.07.001. Triazine antiprotozoals, including diclazuril and toltrazuril, may be effective. Always let your veterinarian prescribe a phenobarbital dosage for dogs. It is CRITICAL to clean the environment to rid it of coccidia. If they are not available, follow their directions in contacting an emergency facility. Most catteries have issues with coccidiosis in young kittens around 5 weeks of age, meaning treatment should be given around day 28 so as to kill the early stages of the protozoa. 2015 May;114(5):2003-6. doi: 10.1007/s00436-015-4408-0. The dose is 10 mg per pound of body weight given once daily for 3-6 days. An official website of the United States government. Disclaimer. Option size 2: Toltrazuril is primarily used to treat coccidiosis, a type of intestinal infection caused by the protozoan parasite, Eimeria. Three 10cc oral syringes of Toltrazuril 2.5% solution. Tijdschr Diergeneeskd. Our 2.5% solution affects all intracellular structures of the one-celled protozoan parasite called Sarcocystis neurona. Under research conditions, a 10x overdose of ponazuril repeated for 3 days caused no adverse effect on beagle puppies. [Diarrhea, pup mortality and Cystoisospora species (coccidiosis)]. On 12dpi, four of six non-treated puppies died. Liquid Toltrazuril that can kills coccidia with one or two doses. Differential diagnoses including bacterial infection (Campylobacter spp, Clostridium spp, Escherichia coli, Salmonella spp, etc) can be detected by culture. Most catteries have issues with coccidiosis in young kittens around 5 weeks of age, meaning treatment should be given around day 28 so as to kill the early stages of the protozoa. Most anti-seizure drugs have a very short half-life, meaning they are quickly removed from the body by the liver or the kidneys. Coccidia, Cystoisospora ohioensis, Toxoplasma andNeospora caninum. Keratoconjunctivitis sicca (KCS) has been reported in some dogs, particularly in breeds with a predisposition to KCS. o [alopecia OR hair loss ], , BVetMed, PhD, DECBHM, DECSRHM, Anthony H. Andrews. Such testing should be done: It is not possible to cure seizures with phenobarbital. Your dog may accidentally bite during a seizure. 25 mg/kg daily for 1 day (C . On 12 dpi, four of six non-treated puppies died. It is important to take preventive measures to reduce the risk of protozoal infections in dogs. It is an effective, safe, and affordable treatment option for many canine health problems, and it is easy to administer. The effects of toltrazuril treatment on cystoisosporosis were studied under experimental and field conditions. Unable to load your collection due to an error, Unable to load your delegates due to an error. No information regarding drug interactions was found. If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. This condition may last from one to several minutes. -stops oocyst shedding Never give your pet two doses at once or give extra doses. Toltrazuril for Dogs: A Comprehensive Guide. Vitamins & Supplements for Race Horses, Dogs / Greyhounds, Camels, Alpacas, & Racing Pigeons. HHS Vulnerability Disclosure, Help It should be used cautiously in pregnant or lactating pets as safety has not been established. In these instances, follow your veterinarians directions and cautions very carefully as their directions may be significantly different from those on the label. Seizures can cause injuries and brain damage, but anti-seizure medication for dogs can prevent or control seizures. The dose of Toltrazuril 2.5% suspension is 10 mg/kg, or 5 mg/0.2 mL per pound. Also see pet health content regarding coccidiosis in dogs Disorders Caused by Protozoa in the Digestive System of Dogs Protozoa are single-celled organisms that can sometimes cause disease. There is relatively little information in the literature regarding its clinical use other than case reports, but interest in the newer anti-coccidial drugs has increased due to the development of parasite resistance. Please select your state below. The https:// ensures that you are connecting to the Natural infections are common in conventional dog breeding facilities. 1.5cc per 10 pounds of dog Dose once. DO NOT use this drug in pregnant cats as the teratogenic effects of this drug has not been adequately researched as of now. Repeat in 2 wks. doi: 10.1007/s00436-011-2398-0. -improves growth rate High fecal shedding of oocysts is associated with clinical signs of disease, especially in kittens. Under experimental conditions, the non-treated puppies excreted oocysts beginning at 6 dpi and suffered from catarrhalic to haemorrhagic diarrhoea. Active ingredient in. horse - 400ml. The dose of Toltrazuril 2.5% suspension is 10 mg/kg, or 5 mg/0.2 mL per pound. Rest assured that they'll be able to help you. Toltrazuril is designed to dose cats before the presence of clinical signs. The coccidiosis does a fine job of that on its own. An official website of the United States government. Treatment with both toltrazuril doses significantly reduced oocyst excretion. This can include regularly deworming the dog, practicing good hygiene and sanitation, and preventing the dog from encountering contaminated water or feces. Ponazuril Bayer Marquis Paste Coccidiosis 10mg Give once. 10 lb. 1987 Nov;17(6):1405-20 Use of them does not imply any affiliation with or endorsement by them. PMC Dogs may shed oocysts in feces but remain asymptomatic. Yes one dose at 10 days to 3 weeks old for prevention then booster as needed. Histologic examination in cats shows asexual stages in the epithelial cells of both surface and crypt cells. The dose of Toltrazuril 5% suspension is 20 mg/kg, or 10 mg/0.2 mL per pound. ", Biomed Central Veterinary Research: "Antiepileptic drugs' tolerability and safety a systematic review and meta-analysis of adverse effects in dogs." While other drugs have been used to control Coccidia infections, they do not provide a cure, and the animal may continue to be infectious to other animals. Toltrazuril 2.5% has a unique mode of action and there is no reason to be concerned with an adverse reaction or a drug-drug reaction. o [ canine influenza] Parasitol Res. Use to remove results with certain terms Cryptosporidia fecal examination is used to for detection of cryptosporidial oocysts. Fecal contamination of feed and water should be prevented. Runs, cages, and utensils should be disinfected daily. Ponazuril may be used to treat Neospora, Toxoplasma and coccidiosis in dogs and cats. The drug can not penetrate the oocyst wall to kill this stage, but treatment at the first signs of a clinical case will still help to limit the severity and duration of the infection as the Toltrazuril will kill single cell stages that have not reproduced sexually yet. Intercurrent disease(s), infectious or iatrogenic immunosuppression, or the stresses of environmental changes (i.e., shipment to pet stores or relocation to pet owners) may exacerbate coccidiosis. and transmitted securely. 2018 Nov 15;263:34-48. doi: 10.1016/j.vetpar.2018.09.016. official website and that any information you provide is encrypted It is an effective, safe, and affordable treatment option for many canine health problems, and it is easy to administer. FOR USE WITH CATS: Most infections in cats and dogs are without clinical signs. Blood level measurement helps veterinarians find the best dose for your dog. Then as needed. Price excludes VAT (USA) It can also be used to treat toxoplasmosis in cats. Use OR to account for alternate terms Convenient single oral dose for easy administration - follow up treatment is usually not necessary. Vet Parasitol. No adverse effects due to treatment were noted in either study. If you are treating a current coccidia case then booster in 10 days. In dogs, the prepatent period is about 3 weeks. Log in to browse, order and prescribe from our compounded drugs formulary.
Note: Safe for Dogs. If you can identify oocysts in fecal exam, the protozoa has completed its reproductive cycle. 2000 Oct;86(10):797-9 National Library of Medicine How Is Ponazuril Administered? Toltrazuril 2.5% 200mL Horses Greyhounds Camels Alpacas Pigeons. PMC Also, in severe infections, there is villous atrophy and excessive mucus production. This content is informational/educational and is not intended to treat or diagnose any disease or patient. $ 82.99 $ 72.99 Toltrazuril 2.5% - 200mL Horses Greyhounds Camels Alpacas Pigeons. 2011 Aug;109 Suppl 1:S37-43. The intent is to kill the protozoa before there is damage to the villi to clear the infection. This site needs JavaScript to work properly. Cystoisospora is pathogenic for puppies and can induce severe disease. 2008 Feb;10(1):1-8 your institution. It's important to not stop administering the drug or reduce the dose because of these side effects. in a dose of 7 mg of active ingredient ( toltrazuryl) by 2.2lb ( 1kg ) of poultry weight, which corresponds to 28 ml Baycox 2,5% solution per 220lb ( 100 kg ) live weight of poultry. Intestinal cells remain intact and functional while the single cell stages of the cocci are dead, as evidenced by staining techniques in studies. The most common coccidia of cats and dogs are Isospora spp. Enter search terms to find related veterinary topics, multimedia and more. The legacy of this great resource continues in the online and mobile app versions today. A single oral treatment for puppies in the 3rd or 4th week of age is recommended. Your veterinarian will test liver function with blood tests at regular intervals to guard against this risk. Some dogs on phenobarbital become hyperactive and aggressive. With proper use, toltrazuril can help to resolve the symptoms of coccidiosis and prevent serious health complications in infected dogs. Some states restrict the information we may provide about controlled substances. They have been used in very few dogs, but diclazuril (5 mg/kg, PO, once) is reported effective in cats. This is a preview of subscription content, access via Other adverse effects include diarrhea, vomiting, poor appetite, and itching. government site. Joachim A, Guerra N, Hinney B, Hodi A, Karembe H, Shrestha A, Sperling D. Parasit Vectors. By clicking Subscribe, I agree to the WebMD, Encephalitis, an inflammation of the brain, Meningitis, an inflammation of the coverings of the brain, Has prolonged seizures (lasting more than 5 minutes), Has seizures that occur in a cluster (two or more seizures in one 24-hour period), Two to four weeks after starting phenobarbital, Two to four weeks after changing the dose, Three months after first starting treatment, Every 6 months while treatment is ongoing, Whenever seizure control is unsatisfactory. Note that it is .1, not 1. It is reported effective. The site is secure. Abstract. Twenty-four puppies were experimentally infected each with 4 x 10(4) oocysts of the Cystoisospora ohioensis group. In addition to its use in the treatment of coccidiosis, toltrazuril is also used to treat other types of parasitic infections in dogs. Toltrazuril is used to treat coccidiosis and other types of protozoal infections in dogs and cats. University of Veterinary Medicine, Komenskeho 73, 04001 Kosice, Slovak Republic, , , , , You can also search for this author in Toltrazuril has been shown to be effective in treating these infections, although it is not always the first line of treatment. All rights reserved. JA: OK. No obvious pain. If you can identify oocysts in fecal exam, the protozoa has completed its reproductive cycle. Use for phrases The coccidiosis does a fine job of that on its own. Your dog might also suffer a fall or accident during a seizure. Submit Office Orders & Patient Prescriptions, Discussion Guide for Pet Owners and Veterinarians, Medication Information for Pet and Horse Owners. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. . Neither dogs nor cats have Eimeria. -, Vet Clin North Am Small Anim Pract. Some of the more common diseases caused by protozoa in dogs are discussed below. read more and cats Disorders Caused by Protozoa of the Digestive System in Cats Protozoa are single-celled organisms that can sometimes cause disease. Save my name, email, and website in this browser for the next time I comment. It is CRITICAL to clean the environment to rid it of coccidia. Merck & Co., Inc., Rahway, NJ, USA(known as MSD outside of the US and Canada) is dedicated to using leading-edge science to save and improve lives around the world. Although some species are widespread, clinical disease is uncommon and usually mild. Acute cases are associated with some diarrhea. Infection with I rivolta takes place in the small intestine. Bethesda, MD 20894, Web Policies Parasitol Res. Comparison of an injectable toltrazuril-gleptoferron (Forceris) and an oral toltrazuril (Baycox) + injectable iron dextran for the control of experimentally induced piglet cystoisosporosis. "Treatment in canine epilepsy a systematic review. It is also effective in preventing the shedding of oocysts, which helps to reduce the spread of the disease to other dogs. However, this cycle is usually considered to maintain the life cycle but not sufficient to cause disease in most animals. The drug can not penetrate the oocyst wall to kill this stage, but treatment at the first signs of a clinical case will still help to limit the severity and duration of the infection as the Toltrazuril will kill single cell stages that have not reproduced sexually yet. During prolonged use, phenobarbital in dogs can damage . Most catteries have issues with coccidiosis in young kittens around 5 weeks of age, meaning treatment should be given around day 28 so as to kill the early stages of the protozoa. doi: 10.1007/s00436-011-2401-9. A single oral application of toltrazuril abrogated oocyst shedding and the treated puppies remained generally coproscopically negative during the following 24weeks. Pet Care Tips However, the efficacy of the drug is independent from the severity of the infection. Preventive medication is usually not necessary. Toltrazuril suspension or microgranulate were given once in a dose of 10 or 20 mg/kg body weight, respectively, to naturally infected puppies in conventional dog breeding facilities, depending on the coproscopical evidence of infection. Once-verbally. When clinical coccidiosis is present it is often related to intercurrent infections, immunosuppression, or stress. Would you like email updates of new search results? Toltrazuril is designed to dose cats before the presence of clinical signs. May Be Prescribed by Vets for: Your veterinarian will start such medication if your dog: When used in dogs, phenobarbital often successfully controls seizures. Efficacy of emodepside/toltrazuril suspension (Procox oral suspension for dogs) against mixed experimental Isospora felis/Isospora rivolta infection in cats. PubMedGoogle Scholar, Received: 2 February 2000 / Accepted: 4 February 2000, Daugschies, A., Mundt, HC. Krautwald-Junghanns ME, Zebisch R, Schmidt V. J Avian Med Surg. In a published study, a single dose of Toltrazuril cured coccidiosis in puppies, as long as adequate environmental cleanup is performed. The drug is categorized as a barbiturate. The most common side effects are mild gastro-intestinal upset including vomiting and diarrhea. 2020 Toltrazuril.net - All Rights Reserved.
Note: Safe for Dogs. In dogs and cats, toltrazuril has been used to treat isosporiasis and hepatozoonosis, although infection may persist in some animals. Rania Gollakner, BS, DVM, MPH, Contributors: Rania Gollakner, BS, DVM, MPH. National Library of Medicine Thus, cystozoites of I felis are found in lymph nodes and abdominal viscera in paratenic hosts such as mice and rats and infective stages are released in the cats intestines. The intent is to kill the protozoa before there is damage to the villi to clear the infection. Cattle from 2 weeks of age at a dose of 15 mg of toltrazuril per 2.2 pounds (1 kg) of animal weight, This drug stabilizes the brain cells and prevents the unregulated electrical discharges in the brain that cause seizures. Oral administration of 0.4ml per pound. With an online account, access our extensive formulary or over 40,000 unique items - 24 hours a day, 7 days a week. Any dog can have seizures, but some breeds are more likely to have them. Toltrazuril is administered orally, usually in the form of a tablet or liquid suspension. Results of this study suggest that administration of toltrazuril at 50 mg/kg (5x to 10x anticipated clinical dosage) for 10 days resulted in only mild clinical abnormalities. 1 ml contains: Toltrazuril - 50 mg; Baycox 5% is administered orally to Rabbits. by K9Sport on 18 February 2013 - 21:02. Ponazuril (brand names: Toltrazuril sulfone, Marquis, Ponalrestat) is an antiprotozoal medication used to treat equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona.
Note: Safe for Dogs. If you can identify oocysts in fecal exam, the protozoa has completed its reproductive cycle. 2000 Oct;86(10):797-9 National Library of Medicine How Is Ponazuril Administered? Toltrazuril 2.5% 200mL Horses Greyhounds Camels Alpacas Pigeons. PMC Also, in severe infections, there is villous atrophy and excessive mucus production. This content is informational/educational and is not intended to treat or diagnose any disease or patient. $ 82.99 $ 72.99 Toltrazuril 2.5% - 200mL Horses Greyhounds Camels Alpacas Pigeons. 2011 Aug;109 Suppl 1:S37-43. The intent is to kill the protozoa before there is damage to the villi to clear the infection. This site needs JavaScript to work properly. Cystoisospora is pathogenic for puppies and can induce severe disease. 2008 Feb;10(1):1-8 your institution. It's important to not stop administering the drug or reduce the dose because of these side effects. in a dose of 7 mg of active ingredient ( toltrazuryl) by 2.2lb ( 1kg ) of poultry weight, which corresponds to 28 ml Baycox 2,5% solution per 220lb ( 100 kg ) live weight of poultry. Intestinal cells remain intact and functional while the single cell stages of the cocci are dead, as evidenced by staining techniques in studies. The most common coccidia of cats and dogs are Isospora spp. Enter search terms to find related veterinary topics, multimedia and more. The legacy of this great resource continues in the online and mobile app versions today. A single oral treatment for puppies in the 3rd or 4th week of age is recommended. Your veterinarian will test liver function with blood tests at regular intervals to guard against this risk. Some dogs on phenobarbital become hyperactive and aggressive. With proper use, toltrazuril can help to resolve the symptoms of coccidiosis and prevent serious health complications in infected dogs. Some states restrict the information we may provide about controlled substances. They have been used in very few dogs, but diclazuril (5 mg/kg, PO, once) is reported effective in cats. This is a preview of subscription content, access via Other adverse effects include diarrhea, vomiting, poor appetite, and itching. government site. Joachim A, Guerra N, Hinney B, Hodi A, Karembe H, Shrestha A, Sperling D. Parasit Vectors. By clicking Subscribe, I agree to the WebMD, Encephalitis, an inflammation of the brain, Meningitis, an inflammation of the coverings of the brain, Has prolonged seizures (lasting more than 5 minutes), Has seizures that occur in a cluster (two or more seizures in one 24-hour period), Two to four weeks after starting phenobarbital, Two to four weeks after changing the dose, Three months after first starting treatment, Every 6 months while treatment is ongoing, Whenever seizure control is unsatisfactory. Note that it is .1, not 1. It is reported effective. The site is secure. Abstract. Twenty-four puppies were experimentally infected each with 4 x 10(4) oocysts of the Cystoisospora ohioensis group. In addition to its use in the treatment of coccidiosis, toltrazuril is also used to treat other types of parasitic infections in dogs. Toltrazuril is used to treat coccidiosis and other types of protozoal infections in dogs and cats. University of Veterinary Medicine, Komenskeho 73, 04001 Kosice, Slovak Republic, , , , , You can also search for this author in Toltrazuril has been shown to be effective in treating these infections, although it is not always the first line of treatment. All rights reserved. JA: OK. No obvious pain. If you can identify oocysts in fecal exam, the protozoa has completed its reproductive cycle. Use for phrases The coccidiosis does a fine job of that on its own. Your dog might also suffer a fall or accident during a seizure. Submit Office Orders & Patient Prescriptions, Discussion Guide for Pet Owners and Veterinarians, Medication Information for Pet and Horse Owners. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. . Neither dogs nor cats have Eimeria. -, Vet Clin North Am Small Anim Pract. Some of the more common diseases caused by protozoa in dogs are discussed below. read more and cats Disorders Caused by Protozoa of the Digestive System in Cats Protozoa are single-celled organisms that can sometimes cause disease. Save my name, email, and website in this browser for the next time I comment. It is CRITICAL to clean the environment to rid it of coccidia. Merck & Co., Inc., Rahway, NJ, USA(known as MSD outside of the US and Canada) is dedicated to using leading-edge science to save and improve lives around the world. Although some species are widespread, clinical disease is uncommon and usually mild. Acute cases are associated with some diarrhea. Infection with I rivolta takes place in the small intestine. Bethesda, MD 20894, Web Policies Parasitol Res. Comparison of an injectable toltrazuril-gleptoferron (Forceris) and an oral toltrazuril (Baycox) + injectable iron dextran for the control of experimentally induced piglet cystoisosporosis. "Treatment in canine epilepsy a systematic review. It is also effective in preventing the shedding of oocysts, which helps to reduce the spread of the disease to other dogs. However, this cycle is usually considered to maintain the life cycle but not sufficient to cause disease in most animals. The drug can not penetrate the oocyst wall to kill this stage, but treatment at the first signs of a clinical case will still help to limit the severity and duration of the infection as the Toltrazuril will kill single cell stages that have not reproduced sexually yet. During prolonged use, phenobarbital in dogs can damage . Most catteries have issues with coccidiosis in young kittens around 5 weeks of age, meaning treatment should be given around day 28 so as to kill the early stages of the protozoa. doi: 10.1007/s00436-011-2401-9. A single oral application of toltrazuril abrogated oocyst shedding and the treated puppies remained generally coproscopically negative during the following 24weeks. Pet Care Tips However, the efficacy of the drug is independent from the severity of the infection. Preventive medication is usually not necessary. Toltrazuril suspension or microgranulate were given once in a dose of 10 or 20 mg/kg body weight, respectively, to naturally infected puppies in conventional dog breeding facilities, depending on the coproscopical evidence of infection. Once-verbally. When clinical coccidiosis is present it is often related to intercurrent infections, immunosuppression, or stress. Would you like email updates of new search results? Toltrazuril is designed to dose cats before the presence of clinical signs. May Be Prescribed by Vets for: Your veterinarian will start such medication if your dog: When used in dogs, phenobarbital often successfully controls seizures. Efficacy of emodepside/toltrazuril suspension (Procox oral suspension for dogs) against mixed experimental Isospora felis/Isospora rivolta infection in cats. PubMedGoogle Scholar, Received: 2 February 2000 / Accepted: 4 February 2000, Daugschies, A., Mundt, HC. Krautwald-Junghanns ME, Zebisch R, Schmidt V. J Avian Med Surg. In a published study, a single dose of Toltrazuril cured coccidiosis in puppies, as long as adequate environmental cleanup is performed. The drug is categorized as a barbiturate. The most common side effects are mild gastro-intestinal upset including vomiting and diarrhea. 2020 Toltrazuril.net - All Rights Reserved.
Note: Safe for Dogs. In dogs and cats, toltrazuril has been used to treat isosporiasis and hepatozoonosis, although infection may persist in some animals. Rania Gollakner, BS, DVM, MPH, Contributors: Rania Gollakner, BS, DVM, MPH. National Library of Medicine Thus, cystozoites of I felis are found in lymph nodes and abdominal viscera in paratenic hosts such as mice and rats and infective stages are released in the cats intestines. The intent is to kill the protozoa before there is damage to the villi to clear the infection. Cattle from 2 weeks of age at a dose of 15 mg of toltrazuril per 2.2 pounds (1 kg) of animal weight, This drug stabilizes the brain cells and prevents the unregulated electrical discharges in the brain that cause seizures. Oral administration of 0.4ml per pound. With an online account, access our extensive formulary or over 40,000 unique items - 24 hours a day, 7 days a week. Any dog can have seizures, but some breeds are more likely to have them. Toltrazuril is administered orally, usually in the form of a tablet or liquid suspension. Results of this study suggest that administration of toltrazuril at 50 mg/kg (5x to 10x anticipated clinical dosage) for 10 days resulted in only mild clinical abnormalities. 1 ml contains: Toltrazuril - 50 mg; Baycox 5% is administered orally to Rabbits. by K9Sport on 18 February 2013 - 21:02. Ponazuril (brand names: Toltrazuril sulfone, Marquis, Ponalrestat) is an antiprotozoal medication used to treat equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona.