DeFronzo RA. However, there was no significant difference in body length in all rats. All data is backed up multiple times a day and encrypted using SSL certificates. The information on healthmatters.io is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. For biosynthetic reasons, most saccharides are almost always more abundant in nature as the "D"-form, or structurally analogous to D-glyceraldehyde. L-Arabinose improved the glycometabolism and insulin resistance. Terms like "pent" for five carbons and "hex" for six carbons are also in common use. PPAR in hepatic tissue plays a key role in the development of hepatic steatosis (32). An official website of the United States government. Effects of L-arabinose supplementation on the mRNA levels of inflammatory cytokines. Martnez-Abundis E, Mndez-Del Villar M, Prez-Rubio KG, Zuiga LY, Cortez-Navarrete M, Ramrez-Rodriguez A, Gonzlez-Ortiz M. World J Diabetes. 2022 Dec 7;11(5):2232-2242. doi: 10.1002/fsn3.3136. Look at the disaccharide and focus on the oxygen which links the two rings together. After L-arabinose treatment, the level of adiponectin increased by 22.2%, while leptin and TNF- decreased by 11.1% and 13.6%, respectively. These results showed that L-arabinose may protect the kidney and heart to a certain degree. All of the rats were randomly divided into four groups according to the following protection: Control Group (Control, n=12): normal rats were fed with normal chows, and distilled water was administrated by gavage for the following 6 weeks; Control+L-arabinose Group (Control+LA, n=12): normal rats were fed with normal chows, and L-arabinose (400 mg/kg bodyweight/day) was administrated by gavage for the following 6 weeks; Model Group (Model, n=12): metabolic syndrome rats were fed with the HCHF diet, and distilled water was administrated by gavage for the following 6 weeks; Model+L-arabinose Group (Model+LA, n=12): model rats were fed with the HCHF diet, and L-arabinose (400 mg/kg bodyweight/day) was administrated by gavage for the following 6 weeks. It had been reported that the dose of 1 g/kg L-arabinose did not cause diarrhea in rats and the LD50 value was 20 g/kg orally. Cong WN, Tao RY, Tian JY, Liu GT, Ye F. The establishment of a novel non-alcoholic steatohepatitis model accompanied with obesity and insulin resistance in mice. It has been suggested by the Food and Drug Administration that the extrapolation of animal dose to human dose should be performed through the body surface area comparisons. L-Arabinose administration prevented obesity, lowered SBP, DBP, and FBG in rats induced by high-carbohydrate, high-fat (HCHF) diet. 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Bethesda, MD 20894, Web Policies Navigate to Metabolic Analysis Markers (Urine). L-Arabinose is a pentose, produced by mild acid hydrolysis of sugar beets, and is absorbed from the intestinal tract in rats with a lower rate compared to glucose. All these changes might play an important role in improving insulin sensitivity. Carbohydrates serve as the main source of energy in diets fed to pigs. Would you like email updates of new search results? Xylose and arabinose is the major constituents of hemicellulose, large quantities of which are found in agricultural waste, such as rice straw, corncobs, and parts of hard wood. Not all bacterial groups have the same nutritional requirement and biochemical properties. The consumption of 2 g/day L-arabinose in adults (60 kg) does not cause any adverse effects on health (19). L-Arabinose, metabolic syndrome, hypertension, insulin resistance, adipocytokines. Glucose and lipid-lowering drugs and insulin-sensitizing drugs have been widely used in the treatment of metabolic syndrome. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. -, Unger RH. 2005;111:144854. We'll look at them in more detail next time. Small pieces of liver and epididymal white adipose tissue (about 10 g) were fixed in 10% neutral formalin solution and embedded in paraffin. Huang PL. Vincent HK, Taylor AG. The biochemical index and histological analysis were measured, and the expression levels of genes related to fatty acid metabolism were analyzed using real-time PCR. Metrics Abstract Catabolite repression refers to the process where the metabolism of one sugar represses the genes involved in metabolizing another sugar. FOIA Caffeine prevents cognitive impairment induced by chronic psychosocial stress and/or high fat-high carbohydrate diet. In theory, this may block some binding sites for coenzyme pyridoxal phosphate, biotin or lipoic acid at the lysyl residue in apoenzyme proteins. It is suspected that the arabitol produced by yeasts in the gastrointestinal tract is absorbed in the portal circulation, and is then converted into arabinose by the liver. and transmitted securely. These may all account for the mechanisms of L-arabinose on the reduction of insulin resistance. Circulation. Accessibility However, L-arabinose supplement improved the degree of viscera injury, suggesting that L-arabinose protects the viscera state of metabolic syndrome rats. Novel nutraceutic therapies for the treatment of metabolic syndrome. The concentration of FFA in the Model group was 1.9-fold higher than the Control group. Unauthorized use of these marks is strictly prohibited. The liver, kidney, and heart were damaged to some extent in rats fed with a HCHF diet. Keywords: -, Chen J, Muntner P, Hamm LL, Jones DW, Batuman V, Fonseca V, et al. Application of natural product-inspired diversity-oriented synthesis to drug discovery. All values are the meanSD. Accessibility StatementFor more information contact us atinfo@libretexts.org. Abstract. He made the assumption that it was one of the ones above so that he could work on the diastereoisomeric part of the problem, hoping that later work would resolve the question of which enantiomer best represented glucose. (a) Gene, Changes in hepatic expression of genes involved in fatty acid metabolism and gluconeogenesis., MeSH Enzyme standard instrument was purchased from Thermo Company (Waltham, USA). Histological sections of liver and white adipose tissue. The corresponsive AUC over 2 h was shown (A2, B2). We strive to make the data entry process easy for you. Liu X, Zhu D, Sun L, Gao Y, Wang C. Effect of L-arabinose on the postprandial blood glucose and body weight. and transmitted securely. Miao sour soup influences serum lipid via regulation of high-fat diet-induced intestinal flora in obese rats. (a) normal liver histology of Control rats; (b) normal liver histology of Control+LA rats; (c) steatosis, inflammation and, fibrosis in Model rats; (d) attenuated lipid deposition and inflammation in Model+LA rats; (e) normal WAT histology of Control rats; (f) normal WAT histology of Control+LA rats; (g) hypertrophic adipocytes in Model rats; (h) smaller adipocytes in Model+LA rats. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. The differential loss of arabinose relative to mannose indicated removal of the major carbohydrate fraction of the seed and enrichment of the protein content. Metabolism and Health Effects of Rare Sugars in a CACO-2/HepG2 Coculture Model. This syndrome has become a significant public health problem worldwide because it is associated with an increased risk for stroke, type-2 diabetes, arteriosclerosis, myocardial infarction, and chronic kidney disease (3, 4). It tests for the presence of acid and/or gas produced from carbohydrate fermentation. Your test results may not mean you have a problem. In addition to the inhibition of digestive enzymes, L-arabinose also shows the protective effect on beta-cell, thus improving glucose tolerance in type-2 diabetic rats (21). This page titled 1.17: Carbohydrates- Monosaccharides is shared under a CC BY-NC-SA 4.0 license and was authored, remixed, and/or curated by Kirk McMichael. Here, our results showed a function of l-Ara during ABA-mediated seed germination. (a) normal liver histology of Control rats; (b) normal liver histology of Control+LA rats; (c) steatosis, inflammation and, fibrosis in Model rats; (d) attenuated lipid deposition and inflammation in Model+LA rats; (e) normal WAT histology of Control rats; (f) normal WAT histology of Control+LA rats; (g) hypertrophic adipocytes in Model rats; (h) smaller adipocytes in Model+LA rats. The difference changed to 1.2-fold at the end of the treatment period, which suggests that L-arabinose has an ability of lowering FFA levels in metabolic syndrome rats. This site needs JavaScript to work properly. Pentose metabolism in the recombinant strains of S. cerevisiae is also considered for comparison. have described an improved Z. mobilis strain capable of producing ethanol from xylose and arabinose ( Figure 1 ). Alzoubi KH, Khabour OF, Salah HA, Abu Rashid BE. The information on healthmatters.io is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. Seri K, Sanai K, Matsuo N, Kawakubo K, Xue C, Inoue S. L-arabinose selectively inhibits intestinal sucrase in an uncompetitive manner and suppresses glycemic response after sucrose ingestion in animals. However, the changes were reversed to normal levels after L-arabinose treatment (Fig. Carbohydrates (sugars) are the most abundant organic molecules in nature. A total of 24 metabolic syndrome rats were selected for further study. HHS Vulnerability Disclosure, Help How about the "sugars" we saw last time with just 4 carbons. The levels of body weight, Lee's index, and visceral index of experimental rats are shown in Fig. It can be classified as either a methyl- pentose or a 6-deoxy- hexose. Arabinose is a breakdown product of hyaluronic acid; also found in certain foods. Your email address will not be published. 2002;53:31936. *. Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Engineering and Biotechnology, Tianjin University of Science & Technology, Tianjin, China. Arabinose is an aldopentose a monosaccharide containing five carbon atoms, and including an aldehyde (CHO) functional group. 0 - 96 mmol/mol creatinine. The rats induced by the HCHF diet developed insulin resistance, indicated by higher FBG, higher FINS and higher HOMA-IR. If the OH group on the stereogenic carbon farthest from the aldehyde group is to the right in the Fischer projection, then the compound is a D-sugar. Accessibility Marcaurelle LA, Johannes CW. To further evaluate the degree of liver injury and the potential effect of L-arabinose in the metabolic syndrome model, serum ALT and AST levels were determined. Sutherland JP, McKinley B, Eckel RH. Thoughts on health, lab results, and lifestyle HealthMatters Blog. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Jurgonski A, Krotkiewski M, Juskiewicz J, Billing-Marczak K. Suppression of postprandial glycaemia by L-arabinose in rats is more associated with starch than sucrose ingestion short report. Before Furthermore, all visceral adipose tissues, including perirenal, retroperitoneal, and epididymal fat pad, were carefully removed and used to calculate the adiposity index (adiposity index (%)=visceral adipose tissues weight (g)/body weight (g)100). The skeletal muscle homogenate prepared in 10% potassium chloride solution chilled on ice was used to measure the activity of GLUT4. *p<0.05, **p<0.01 vs. Control; # 3c) compared to livers from the Control group (Fig. The purpose of this study was to investigate the effects of L-arabinose on hypertension, insulin resistance, and adipocytokines in rats with metabolic syndrome induced by a HCHF diet. Compared with other functional sugars, L-arabinose has its own advantages, such as a wide variety of sources, low sweetness, low cost, and so on. Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans. Serum was separated by centrifugation at 3,000g for 15 min at 4C and stored at 80C for further analysis. All values are the meanSD. He also had a polarimeter so he could determine whether a sample was optically active or not. Poudyal H, Panchal SK, Ward LC, Waanders J, Brown L. Chronic high-carbohydrate, high-fat feeding in rats induces reversible metabolic, cardiovascular, and liver changes. Zhao L, Wang Y, Zhang G, Zhang T, Lou J, Liu J. Nutrients. L-Arabinose has a very similar taste to sucrose, but with half the sweetness of sucrose; furthermore, it is not involved in metabolic processes in animals, thus L-arabinose is a non-caloric sugar. We understand that to mean that it is a sugar having six carbons in a straight unbranched chain which ends in an aldehyde group. In-depth research on any test at your fingertips, all stored and tracked in one place. As previously mentioned, first strand cDNA was synthesized using the PrimeScript RT reagent Kit and PCR-amplification was performed (20 L volume) using 2 M for each primer (Table 1), 50 ng of cDNA and 10 L of SYBR Primix Ex-Tag. [4], Arabinose gets its name from gum arabic, from which it was first isolated. Chen J, Muntner P, Hamm LL, Jones DW, Batuman V, Fonseca V, et al. The area under the glucose-time curse (AUC) was also calculated by the following formula: (AUC0120min = (G0+G30) 30/2 + (G30+G60) 30/2 + (G60+G120) 60/2). The rat's systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured by a non-invasive blood pressure meter every 2 weeks. All values are the meanSD. 6a, the mRNA levels of hepatic ACC in the Model group are significantly higher than that of the Control group. A compound which can have all of its larger substituents (everything is larger than hydrogen) in an equatorial position is more stable than one which cannot. These positions are called "equatorial" to distinguish them from the other positions (roughly perpendicular to the ring, called "axial"). Fischer noticed that if reactions could be developed which changed the aldehyde group into a primary alcohol and the primary alcohol into an aldehyde (switch ends) one of these structures would give itself, and the other would give back a new L sugar. In the case of ribose the important ring (found in RNA) is the five membered ring. L-Arabinose lowered the levels of inflammation factors in rats induced by high nutritious diet. If the OH group is down (in a drawing with the ring oxygen to the rear center or right), the designation for that anomer is alpha. Since the groups at the top and the bottom of the chain are not the same, there are no meso isomers. After the rat model for metabolic syndrome was successfully established, L-arabinose was administrated by oral gavage for 6 weeks. Such six membered rings are named by the term "pyranose." Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, et al. Oral, Histological sections of liver and white adipose tissue. For total-RNA preparation, frozen tissues were ground into fine powder in liquid nitrogen and homogenized in TRIzol solution. Tissues were cut into slices of 36 m thickness and stained with hematoxylineosin (H&E). Federal government websites often end in .gov or .mil. Mohamed AI, Entesar FA, Salwa AI, Walaa YA, Aly MA. Received 2015 Jun 18; Revised 2015 Nov 17; Accepted 2015 Nov 17. Language links are at the top of the page across from the title. However, due to their high prices and severe side effects, there is an urgent need to find some naturally occurring materials to improve treatment (9). Effects of L-arabinose on oral glucose tolerance test and insulin tolerance test. Effect of starvation on hepatic acyl-CoA synthetase, carnitine palmitoyltransferase-I, and acetyl-CoA carboxylase mRNA levels in rats. They are on the right below. Simply attach an image or a file of your lab test results, and one of our qualified data entry team members will add the results for you. The names of the hexoses tell us which diastereoisomer we have; the D or L designation gives us which enantiomer we have. L-Arabinose did not demonstrate differences on mRNA expression between the Control+LA group and the Control group. Effects of L-arabinose on obesity and organ weight in rats. Lessons from animal models. Annu Rev Med. The production of L-arabonate and D-galactonate employing a versatile l-arabinose dehydrogenase (AraDH) from Azospirillum brasilense is presented. Now let's see what we have left. Notice that the carbon in the newly formed hemiacetal group is stereogenic. Interpret your laboratory results instantly with us. Arabinose is a five-carbon sugar with the function of the aldehyde called aldose. As shown in Table 5, serum ALT and AST levels of the Model group rats increased by 134.5% and 90.8%, respectively. As shown in Table 2, there were significant differences in parameters of serum lipid metabolism in the metabolic syndrome group, including hypertriglyceridemia, hypercholesteremia, and an obvious increase in LDL-C. . In addition, SBP of rats in Control+LA group showed no remarkable difference compared to the Control group. The site is secure. Gene expression levels of hepatic PDK4, the rate-limiting enzyme of glucose oxidation, were significantly decreased (87.0%) in the Model group. Wang XX, Ye T, Li M, Li X, Qiang O, Tang CW, Liu R. Mol Med Rep. 2017 Jul;16(1):109-118. doi: 10.3892/mmr.2017.6586. 2016 Apr 10;7(7):142-52. doi: 10.4239/wjd.v7.i7.142. Bhattacharya J, Sood N. Who pays for obesity? The biochemical index and histological analysis were measured, and the expression levels of genes related to fatty acid metabolism were analyzed using real-time PCR. van Laar A, Grootaert C, Van Nieuwerburgh F, Deforce D, Desmet T, Beerens K, Van Camp J. Nutrients. Rats in the metabolic syndrome group had heavier body weight and higher DBP and SBP compared to the control group. *p<0.05, **p<0.01 vs. Control; # Microbial metabolism of l -arabinose has been well characterized for fundamental understanding of metabolic processes [ 5 ] and for biotechnological applications [ 6, 7 ]. HOMA-IR index was determined according to the formula: fasting blood glucose (FBG), fasting insulin (FINS). eCollection 2023 May. The composition of the HCHF diet followed the method of Poudyal and co-workers (11). Origin 8.0 was used for figures. The effect of L-arabinose on HbA1c in experimental rats is showed in Table 4. Glucose, the most common monosaccharide, is an aldohexose. Reagan-Shaw S, Nihal M, Ahmad N. Dose translation from animal to human studies revisited. As previously reported, the disturbance in -oxidation of fatty acids owing to down-regulation of hepatic CPT-1 is a key mechanism in pathogenesis of fatty liver in metabolic syndrome (33, 34). In the present study, a simple, sensitive, selective, and reliable HPLC method using a photodiode array (PDA) detector and an evaporative light [5], Originally commercialized as a sweetener, arabinose is an inhibitor of sucrase, the enzyme that breaks down sucrose into glucose and fructose in the small intestine.[6]. Histological sections of liver and white adipose tissue. Save time on interpreting lab results with the largest database of biomarkers online. (a) normal liver histology of, L-Arabinose lowered the levels of inflammation factors in rats induced by high nutritious, Effects of L-arabinose supplementation on, Effects of L-arabinose supplementation on the mRNA levels of inflammatory cytokines. Commercial kits for the measurement of alanine aminotransferase (ALT), aspartate aminotransferase (AST), free fatty acids (FFA), triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C), and hepatic glycogen were obtained from the Jian Cheng Biotechnology Company (Nanjing, China). Sugars having reducing property react with phenylhydrazine hydrochloride to form characteristic osazones (crystals)..
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