These concerns and the problems they elicit are discussed in the sections below. Mirica, S. N., Duicu, O. M., Trancota, S. L., FiraMladinescu, O., Angoulvant, D., & Muntean, D. M. (2013). By my 3rd-4th dose, the brain pain/dizziness and emotional weirdness stopped. There does not appear to be any reason to encourage use of lithium sulfate over the more thoroughly researched Li2CO3. A two years study, The lithium treatment of maniacal psychosis. Contrasting studies performed in 1978 and 1979 yielded two important findings: (1) LiOr yielded significantly greater concentrations of the lithium ion (Li+) in the brain than was observed for equivalent doses of Li2CO3 (Kling etal., 1978), and (2) LiOr impaired renal function to a greater extent than Li2CO3 when employed at concentrations of 2mmol Li+/kg body weight. Uridine enhances neurite outgrowth in nerve growth factordifferentiated PC12 [corrected]. Taking lithium orotate with calcium may help treat symptoms of hepatitis. Myoinositol is a substrate used for the synthesis of phosphatidylinositol phosphates (Shi etal., 2006), which are signaling molecules involved in a diverse array of processes, including cell growth, cell proliferation, apoptosis, neuronal transmission, and the actions of insulin, among others (Toker, 2002). Branea, I., Gaita, D., Dragulescu, I., Socoteanu, I., Luca, C., Mancas, S., Drgan, S., Iurciuc, M., Velimirovici, D., Gapar, M., Fluture, A., Ionac, A., Deutsch, P., Pescariu, S., Petrescu, L., Branea, H., Mut, B., Din, C., Crsnic, M., & Saru, C. A. Take extra care driving and doing tasks where you need to be alert. Also of note, orotic acid itself may confer antioxidant benefit beyond its role as a mineral carrier (Aonuma etal., 1969; Hassani etal., 2019; Loffler etal., 2016). (Sartori 1986) Other studies show lithium orotate may improve depression associated with bipolar disorder. Lithium in tap water and suicide mortality in Japan, International Journal of Environmental Research and Public Health, Circadian rhythm in bipolar disorder: A review of the literature, Journal of the American Society of Nephrology, Phosphoinositides and signal transduction. After completing the quiz, you can getyour free tailored mini-course, full of integrative practicesand supplement ideasto help you reclaim your most resilient self. Metabolic supplementation with orotic acid and magnesium orotate. Aberrant GSK3 activity has been linked to the disruption of the circadian clock (Cole, 2013; Levenson & Frank, 2011; Paul etal., 2012; Takaesu, 2018), impaired neurogenesis and hippocampal function and/or reduced volume (Elvsshagen etal., 2013; Hartberg etal., 2015; Otten & Meeter, 2015), and decreased expression of neurotrophic factors (Grimes & Jope, 2001; Li etal., 2014; Soares etal., 2016; Yasuda etal., 2009), all of which are pathological processes believed to be associated with BD. How to Improve Your Mood This Winter Season, A Beginners Guide To Yoga | 3 Things You Need To Know Before Unrolling Your Mat, Benefits of Lithium Orotate: According to Triple Board Certified Psychiatrist. It increases sensitivity to serotonin, which is part of its antidepressant effectiveness. Barbosa, I. G., Bauer, M. E., MachadoVieira, R., & Teixeira, A. L. (2014). This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. After several deaths, the Food and Drug Administration (FDA) banned the use of lithium salt substitutes. Received 2021 May 15; Accepted 2021 Jun 8. Stincone, A., Prigione, A., Cramer, T., Wamelink, M. M. C., Campbell, K., Cheung, E., OlinSandoval, V., Grning, N.M., Krger, A., Tauqeer Alam, M., Keller, M. A., Breitenbach, M., Brindle, K. M., Rabinowitz, J. D., & Ralser, M. (2015). Lithium orotate isnt the most common supplement and is typically only recommended for certain conditions or deficiencies, but it does have certain benefits for your overall health. Shortly thereafter, in 1979, Smith and Schou reported a potential for increased risk of renal toxicity for LiOr relative to Li2CO3 in rats when injected at high concentrations, that is, 2mM Li+ (Smith & Schou, 1979). Facilitated transport of uracil and 5fluorouracil, and permeation of orotic acid into cultured mammalian cells, An oldie but goodie: Lithium in the treatment of bipolar disorder through neuroprotective and neurotrophic mechanisms, A nutrient combination that can affect synapse formation. They also claim that it easily passes through the blood-brain barrier, much more so than other lithium forms. The symptoms resolved following reductions in dosage.Sartori 1986, A case report exists of an 18-year-old woman ingesting 18 lithium orotate tablets, each containing 120 mg of lithium orotate. Dobolyi, A., Juhasz, G., Kovacs, Z., & Kardos, J. The pharmacokinetics of lithium oxybutyrate relative to Li2CO3 has not been explored. These concerns effectively curtailed LiOrrelated research for decades. O'Brien, W. T., Harper, A. D., Jove, F., Woodgett, J. R., Maretto, S., Piccolo, S., & Klein, P. S. (2004). When treating these illnesses, dosages of Lithium can reach 1800mg daily. Glycogen synthase kinase3beta haploinsufficiency mimics the behavioral and molecular effects of lithium. Do not use this product if you are pregnant or plan to become pregnant soon. The most common benefits people experience with lithium orotate are: Balanced . While the existing literature suggests that orotate salts present an efficacious means by which to deliver minerals, modern research is lacking. [PMC free article] [PubMed] [CrossRef] [Google Scholar], [Correction added on 30 August 2021, after first online publication: Peer review history statement has been added. During this period, orotic acid was identified as a precursor of pyrimidine biosynthesis (Bergstrm etal., 1949; Smith & Baker, 1959), highlighting its essential role in mammalian metabolism. Unfortunately, concerns were raised in 1979 about the potential for increased renal toxicity relative to Li2CO3 (Smith & Schou, 1979), though given the results noted by Kling etal. Hilty, D. M., Leamon, M. H., Lim, R. F., Kelly, R. H., & Hales, R. E. (2006). You should talk with your health care provider for complete information about the risks and benefits of using this product. While a cause for concern, there are a few factors worthy of note: (1) Stimulated cancerous cell growth was only observed in initiated rats; that is, rats destined for hepatocarcinoma. This information relates to an herbal, vitamin, mineral or other dietary supplement. (1999). High-dose lithium is a prescription drug and must be closely monitored by a physician. Knijff, E. M., Breunis, M. N., Kupka, R. W., de Wit, H. J., Ruwhof, C., Akkerhuis, G. W., Nolen, W. A., & Drexhage, H. (2007). In sum, LiOr may reduce the occurrence of relapse in alcoholism at subtherapeutic doses, while Li2CO3 does not appear to be similarly effective even at markedly higher concentrations, lending credence to the notion that LiOr may be a more efficacious formulation. Lithium in scalp hair of adults, students, and violent criminals. Lithium chloride sees much of its use occur in animal studies, largely due to ease of dosing via intraperitoneal injection. It is important to note that the consequences of lithiummediated IMPase inhibition are less well characterized than GSK3 antagonism within the context of BD. Immunoreactivity of urate transporters, GLUT9 and URAT1, is located in epithelial cells of the choroid plexus of human brains, Pharmacology and structure of P2Y receptors. [1]. (1968). Historically, this compound was believed to be part of the vitamin B complex after it was determined in the 1950s that the previously unidentified growth enhancement factor vitamin B13, first isolated from distiller's dried grains with solubles (i.e., dried animal feed) in the late 1940s (Novak & Hauge, 1948), was in fact orotic acid (Manna & Hauge, 1953). There are now at least three groups of people interested in lithium orotate. McCarty, M. F., & DiNicolantonio, J. J. Helps The Brain Grow And Regenerate Neurons Please Note: When you purchase through links on our site, we may earn an affiliate commission. LiOr was successfully employed in the treatment of mania in the early 1970s by Hans Nieper, an early proponent for the use of orotic acid as a mineral carrier (Nieper, 1970, 1973). Raghu, P., Joseph, A., Krishnan, H., Singh, P., & Saha, S. (2019). Benefits of Lithium Orotate Promotes a positive mental outlook Benefits of Lithium Orotate. . (Lakhan 2008, Nieper 1973) Extrapolation of reported findings is limited by poor methodology of the limited studies. Petrova, T. R., Skibitskii, V. V., Grigor'ev, G. I., Vil'chinskaia, M. N., & Oleinik, N. I. A., Li, X., & Jope, R. S. (2010). LiOr as a replacement for Li2CO3 in the treatment of BD. Comparisons of the pharmacokinetics, safety, and efficacy of LiOr and Li2CO3 are sorely lacking in the literature. In fact, lithium is used commonly by psychiatrists for treating bipolar disorder because it can help stabilize your mood. As lithium may demonstrate antiinflammatory capacities, attenuation of neuroinflammation may present an additional mechanism by which lithium addresses the symptoms of BD. Lithium amplifies agonistdependent phosphatidylinositol responses in brain and salivary glands. Lithium citrate, available in the commercial formulation Litarex, was approved for use in the late 1970s (Fyro, 1975). [3,4] In animal models, lithium was also found to promote increased cytoprotective B-cell activity. A., & Yaropolov, A. I. Boufidou, F., Nikolaou, C., Alevizos, B., Liappas, I. The .gov means its official. A. Discontinue therapy if clinical signs of lithium toxicity occur (eg, diarrhea, vomiting, tremor, mild ataxia, drowsiness or muscular weakness).Lithobid 2016, Lithium 2015, Lithium 2016, A small, open-label study reported mild symptoms of muscle weakness, loss of appetite, mild apathy, and listlessness among some patients taking lithium orotate 150 mg/day. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Depressive states are characterized by feelings of persistent sadness, anhedonia, sleep disturbance, and fatigue, whereas mania and hypomania are noted for euphoria, loss of inhibition, impaired decisionmaking, and/or reduced need for sleep (Association AP, 2013). Lithium improves mitochondrial function, increasing cellular energy output and encouraging damaged mitochondria to be recycled. Slight lithium toxicity, from small doses, can manifest as tremors, weakness, fatigue, headaches, vomiting, and diarrhea. (Barkins 2016) Lithium may also upregulate neurotrophins, such as brain-derived neurotrophic factor (BDNF) and nerve-growth factor (NGF), which are important in neuronal function. Hans Nieper proposed that orotates demonstrate affinity for tissues where metabolism heavily features the pentose phosphate pathway (PPP) and subsequent pyrimidine synthesis, such as glia, vascular endothelium (BBB in particular), and neurons (Nieper, 1973) (Figure3b). in 1980 demonstrated antimanic potential. College of Medicine, Next, orotate phosphoribosyltransferase a component of the bifunctional uridine monophosphate synthase protein complex catalyzes the transfer of ribose5phosphate1pyrophosphate to orotate to form the nucleotide orotidine 5monophosphate (OMP). The return of metabolism: Biochemistry and physiology of the pentose phosphate pathway, Biological Reviews of the Cambridge Philosophical Society. Ive seen a great effect on these individuals within my clinical practice. It's common to typically start with a 2.5 - 5 mg dose in a liquid or tablet form, for 1-2 weeks and then titrate up the dose every 1-2 weeks until target symptoms show improvement, to a maximum dose of around 20 mg daily. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. See terms. (1978) found that LiOr resulted in brain lithium concentrations threefold higher than what were observed for equivalent doses of Li2CO3. Avoid using lithium orotate until more is known. The benefits and drawbacks of Li2CO3 use in BD. . Lithium in drinking water and the incidences of crimes, suicides, and arrests related to drug addictions. Early signs of lithium toxicity include diarrhea, vomiting, drowsiness, muscular weakness, tremors, and lack of coordination. Noncontrolled studies have examined the use of low-dose lithium orotate in the treatment of alcoholism, migraines, and depression associated with bipolar disorder. It is therefore possible that aspects of lithium's therapeutic effects may be elicited through antiinflammatory mechanisms involving GSK3 inhibitiondependent attenuation of microglial proinflammatory responses. Efficacy of lithium as acute treatment of manicdepressive illness. Spectrum of lithium induced thyroid abnormalities: A current perspective. In 2007, Pauz and Brooks submitted a case report for a patient who had ingested 18 LiOr tablets, with each tablet containing 3.83mg of Li+. official website and that any information you provide is encrypted 4 Amazing Health Benefits of Lysine ENCAPSULATION PRACTICES Brilliant B Vitamin Complex Brilliant C Vitamin Complex Lithium Orotate Fulvic Humic Acid Supports Healthy Response to Daily Stress Stress is part of modern life and can even be beneficial in motivating you to achieve your goals. These are drugs like furosemide, hydrochlorothiazide, nonsteroidal anti-inflammatory drugs (NSAIDs), ibuprofen, ramipril, or losartan. In 1976, Donald Smith examined the pharmacokinetics of LiOr, Li2CO3 and lithium chloride, noting minimal differences between the compounds (Smith, 1976). Epub 2007 Nov 13. The mechanism of interaction of carnosine with superoxide radicals in water solutions, Comparison of plasma lithium levels and their interindividual variations with coated lithium carbonate tablets and a mediumslowrelease lithium sulphate preparation (Lithionit Duretter). Trace amounts of it are naturally present in various minerals, water, soil, fruits, vegetables, and other plants that are grown in lithium-rich soil [ 1 ]. I been taking lithium orotate for 6 weeks and my brain feels great. Benefits of calamansi juice include bleaching the skin, detoxifying the body, aiding in weight loss & managing diabetes. At the Bundoora Repatriation Hospital in 1949, John Cade hypothesized that excess uric acid was related to mania and summarily began treatment on 10 manic patients with lithium citrate and Li2CO3, citing the success of Garrod in using lithium to manage gout (Shorter, 2009). Cytokine production in bipolar affective disorder patients under lithium treatment. First, you will have to discard the tough outer leaves of the lemongrass stalks by peeling them away with your fingers. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat. Lithium orotate (LiC 5 H 3 N 2 O 4; henceforth referred to as LiOr), a compound largely abandoned since the late 1970s, may represent such an alternative. Given the known issues associated with Li2CO3 use, perhaps it is time to explore LiOr in greater detail. Bergstrm, S., Arvidson, H., Hammarsten, E., Eliasson, N. A., Reichard, P., & Ubisch, H. V. (1949). Australian & New Zealand Journal of Psychiatry. (Nowak 2020), Lithium has demonstrated a decrease in amyloid and tau proteininduced neurotoxicity in experimental studies. The mood stabilizers lithium and valproate selectively activate the promoter IV of brainderived neurotrophic factor in neurons. [7] In animal models, lithium increased intracellular glutathione levels and reduced oxygen metabolite damage, suggesting that it selectively boosts glutathione-dependent enzymes to protect against free radical stress.[8]. (1978) effectively closed the gates on future inquiries into the use of LiOr. This formulation of Lithium Orotate includes 10 mg of the trace mineral per capsule for a wide range of protocols. The answer may lie in the history of lithium as discussed above. Physiology and Pharmacology, Smith, F. E., Thelwall, P. E., Necus, J., Flowers, C. J., Blamire, A. M., & Cousins, D. A. Protective role of lithium in ameliorating the aluminium-induced oxidative stress and histological changes in rat brain. In sum, orotic acid appears to serve many roles in in the human body, both directly, through its contributions to DNA/RNA synthesis, and (potentially) indirectly, through its downstream metabolites uridine, alanine, and carnosine. However, the mineral lithium (Lithium orotate) is a natural, side effect-free alternative which is very useful for helping to re-regulate circadian rhythms and the sleep-wake cycle.. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. The role of lithium in the treatment of bipolar disorder: Convergent evidence for neurotrophic effects as a unifying hypothesis. Another effect of lithium is that it can help regulate your circadian rhythm, the internal clockthat tells us naturally when to sleep and when to wake up. A.Jr., Mague, S. D., Parow, A. M., Stoll, A. L., Cohen, B. M., & Renshaw, P. F. (2005). Intriguingly, the absence/decreased levels of lithium in drinking water are associated with increased incidence of a host of harmful moodrelated conditions (Schrauzer & Shrestha, 1990; Schrauzer etal., 1992; Sugawara etal., 2013). In support of this, a study by Kling etal. If the increased ease of membrane transport associated with LiOr compared to Li2CO3 is not unique to the BBB and/or elements of the CNS, then the elevated accumulation of lithium within offtarget organs could accelerate development/risk of complications, for example, renal dysfunction. The authors acknowledge funding contributions from the University of Saskatchewan, College of Medicine, via a College of Medicine Research Award grant. It's common for adults to start with 10 mg daily for the first week or two, and then increase to 20 mg daily if needed and well-tolerated. A., & Steckler, T. (2006). OMP is used to form uridine and other associated pyrimidine nucleotides through a series of subsequent steps and intermediated transition states (Evans & Guy, 2004; Lieberman etal., 1955). (1991). Last updated on Nov 21, 2022. (1982). Isolation of the unidentified growth factor, vitamin B13, in distillers' dried solubles. Studies exploring its efficacy have reported a range of different outcomes, from no difference relative to Li2CO3 (Guelen etal., 1992; Shelley & Silverstone, 1986), to significant reductions in peak serum lithium levels (Tyrer etal., 1982). Lithium is thought to contribute to the management of affective disorders through a variety of mechanisms, with the antagonism of GSK3 and IMPase (Yu & Greenberg, 2016) standing as perhaps the most prominent one (Figure1). Some products may not mix well with drugs or other natural products. Lithium is thought to help regulate the neurotransmitter glutamate by keeping the amount of glutamate between brain cells at a stable, healthy level to support healthy brain function. I have to admit, initially, I was skeptical that such a low dosage would have any effect on my clients. From these humble beginnings, lithium has gone on to become the arguable gold standard for the management of the manic component of BD and the prevention of mood episode recurrences (Tondo etal., 2019). Early in its use in medical applications, lithium was administered via a variety of different formulations, such as lithium bromide (Hammond, 1871) and lithium citrate (Fyro, 1975). Dong, H., Zhang, X., Dai, X., Lu, S., Gui, B., Jin, W., Zhang, S., Zhang, S., & Qian, Y. These sentiments are understandable, given that prescription Lithium has significant risks. Shimon, H., Agam, G., Belmaker, R. H., Hyde, T. M., & Kleinman, J. E. (1997). Lithium has many different applications in psychiatry, from depression [5] to ADHD and obsessive-compulsive disorder. Go to the ER right away. It is also used on a daily basis to reduce the frequency and severity of manic episodes. Lithium orotate benefits: Impact on circadian rhythm and sleep One way that lithium interacts with mood is by inhibiting GSK3B (glycogen synthase kinase 3beta). Further work is not only warranted, but imperative to understanding the potential benefits of LiOr. All rights reserved. Our articles are evidence-based and contain scientific references, fact-checked by experts. Peoplewith anorexia and other eating disorders have also had some success with lithium supplementation. Lithium Orotate: A superior option for lithium therapy?. Physiology and pathophysiology of carnosine. Im happy to say I was wrong. If you are taking medication already, be sure to talk with your doctor before adding any of these items. Rosenblat, J. D., & McIntyre, R. S. (2015). While complications such as hypothyroidism can be managed via thyroid supplementation, this is not a desirable outcome. HHS Vulnerability Disclosure, Help While LiOr effectively reduced relapse occurrence at the relatively low dose of 150mg (Sartori, 1986), Li2CO3 demonstrates only mild efficacy at therapeutic dosages, that is, >600mg (Fawcett etal., 1987). A neutral, nondissociated LiOr complex could potentially cross the BBB and cell membranes with greater efficiency than the Li+ and carbonate ions of Li2CO3 (Nieper, 1973; Sartori, 1986), which dissociate readily in solution. Ginger also helps boost bone health, strengthen the immune system, and increase appetite. Photo Credit: Shutterstock. We comply with the HONcode standard for trustworthy health information. Soares, A. T., Andreazza, A. C., Rej, S., Rajji, T. K., Gildengers, A. G., Lafer, B., Young, L. T., & Mulsant, B. H. (2016). Antioxidant potential and angiotensinconverting enzyme (ACE) inhibitory activity of orotic acidloaded gum Arabic nanoparticles. This product is not intended to diagnose, treat, cure, or prevent any disease. In fact, one of the more wellknown cases of LiOr toxicity appears to highlight the safety of the compound. (2009). The adverse effects on the kidneys reported by Smith etal. Laconi, E., Vasudevan, S., Rao, P. M., Rajalakshmi, S., Pani, P., & Sarma, D. S. (1993). Kato, T., Shioiri, T., Takahashi, S., & Inubushi, T. (1991). Elvsshagen, T., Westlye, L. T., Ben, E., Hol, P. K., Andersson, S., Andreassen, O. (1969). - Dr. Izabella Wentz, PharmD - Pharmaceutical lithium can be toxic for the thyroid, but what about nutritional lithium, in small doses? Lithium orotate is a nutritional supplement form of lithium, used in micro doses much like zinc or selenium. Are medical comorbid conditions of bipolar disorder due to immune dysfunction? If so, how does the LiOr complex accomplish this? Lithium Orotate: A superior option for lithium therapy? Chronic treatment with both lithium and sodium valproate may normalize phosphoinositol cycle activity in bipolar patients. Information is limited. Davanzo, P., Thomas, M. A., Yue, K., Oshiro, T., Belin, T., Strober, M., & McCracken, J. Lithium modifies brain arachidonic and docosahexaenoic metabolism in rat lipopolysaccharide model of neuroinflammation. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a specific patient. Lu, S., Huang, W., Li, X., Huang, Z., Liu, X., Chen, Y., Shi, T., & Zhang, J. Considering the lack of literature surrounding LiOr, this review aims to call attention to (1) the history of Li2CO3 use, (2) why Li2CO3 rose to prominence, (3) the issues associated with Li2CO3based therapy, (4) why research into LiOr stagnated, and (5) how future explorations into LiOr as an option in the management of BD are needed. Kibirige, D., Luzinda, K., & Ssekitoleko, R. (2013). Lithium is regarded as a neuroprotective agent. (2014) found that of the 17 treatment options assessed in 33 randomized controlled trials, only lithium and quetiapine prevented manic and depressiveepisode relapse or recurrence when used in monotherapy. Carlezon, W. Furthermore, other studies have shown no effect of Li2CO3 on avoidance of relapse (Dorus etal., 1989), leading some to conclude that Li2CO3 is not an effective treatment for alcoholism (Lejoyeux & Ades, 1993). So, yes, a small dose can be effective and addicting. Kohen, R., Misgav, R., & Ginsburg, I. For oral dosage form (extended-release tablets): For acute mania: Adults and children 12 years of age900 milligrams (mg) 2 times a day, or 600 mg 3 times a day. Is there a test to indicate whether one is low in natural levels of lithium, and what are the optimal blood amounts? Liubimov, B. I., Tolmacheva, N. S., Ostrovskaia, R. U., & Mitrofanov, V. S. (1980). Furthermore, when administered at 2mmol Li+/kg as an orotate, Li+ progressively accumulated within the brain in a manner not observed for Li2CO3; Li2CO3 maintained a steady concentration of 0.5mmol Li+/kg of brain tissue, whereas LiOr increased from 0.5 to 1.3mmol Li+/kg over the course of 24h. Brain lithium concentrations were assayed via flame photometry of tissue homogenates. Sachs, G. S., Printz, D. J., Kahn, D. A., Carpenter, D., & Docherty, J. P. (2000). Lithium had superior benefits in type II patients, with significantly greater reduction of episodes per year and of the percentage of time ill. The authors have no conflict of interest to declare. Lithium orotate is a salt of lithium and orotic acid, and it comes as an over-the-counter (OTC) supplement. They are generally considered safe, however, they shouldnotbe startedwithout your doctors knowledge and supervision. Loffler, M., Carrey, E. A., & Zameitat, E. (2016). Lithium Orotate, the Great Protector. (2018). Surprisingly, this early Danish work with Li2CO3 was seemingly forgotten, as the use of lithium in psychiatry would not experience a revival until 1949 courtesy of Australian psychiatrist John Cade (Shorter, 2009). It has shown potential as a neuroprotective agent against Aluminum-induced oxidative stress and shows promise to protect the brain against free radical damage. Perugi, G., Quaranta, G., Belletti, S., Casalini, F., Mosti, N., Toni, C., & DellOsso, L. (2015). I have found, however, that taking Ginkgo 2-3x a day, instead of one time a day, has helped tremendously with brain fog, memory, clear headedness and the ability to multi task again if I need to. It has also been known to be used to manage depression, mental health issues, and alcoholism. More data are needed before any conclusions can be reached regarding the efficacy and safety of lithium aspartate relative to Li2CO3. If you are considering going off medication, remember never to stop your medication suddenlyalways consult with your doctor about how to safely taper off any psychiatric medication. Curcumin can also limit weight gain. All named authors have seen and approved the final version of the manuscript. 3. Before Lithium Orotate benefits most types of mood disorders A doubleblind, placebocontrolled trial of lithium carbonate therapy for alcoholism. Medically reviewed by Drugs.com. Lithium ameliorates lipopolysaccharideinduced microglial activation via inhibition of tolllike receptor 4 expression by activating the PI3K/Akt/FoxO1 pathway. Tondo, L., Alda, M., Bauer, M., Bergink, V., Grof, P., Hajek, T., Lewitka, U., Licht, R. W., Manchia, M., MllerOerlinghausen, B., Nielsen, R. E., Selo, M., Simhandl, C., & Baldessarini, R. J., & International Group for Studies of Lithium (IGSLi) As Kling etal. Notably, the data for lithium were derived from trials with nonenriched designs, which was not the case for quetiapine (Nolen, 2015). (2014). Lithium Orotate Benefits Lithium orotate has the ability to potentially improve cognitive function, enhance mood, and increase bone strength. It is used in much, much higher doses, in the range of 1000 mg per day, vs. 10-20 mg per day of lithium orotate. (a) Mineral orotates may display limited dissociation in biological solutions, allowing them to exist in sera as nondissociated, electrically neutral compounds. Clinical studies exploring the efficacy of LiOr are sparse, perhaps as a result of the study by Smith and Schou (1979) discussed previously. Although a potential role for the clinical use of lithium orotate for treating or preventing infection caused by the SARS-CoV-2 coronovirus has been proposed, evidence is lacking to support its use. Lithium is used to treat mania that is part of bipolar disorder (manic-depressive illness). 8600 Rockville Pike This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. Studies comparing the pharmacokinetics of lithium sulfate and Li2CO3 have found little to no difference in absorption and/or peak serum lithium concentrations (Persson, 1977), or induction of sideeffects (Edstrom & Persson, 1977). Lithium is present in the diet, mainly in grains and vegetables. Rosenfeldt, F. L., Richards, S. M., Lin, Z., Pepe, S., & Conyers, R. A. While these small doses are likely to be safe, the potential toxic effects of microdosing LiOr still warrants further examination. Chiba, Y., Murakami, R., Matsumoto, K., Wakamatsu, K., Nonaka, W., Uemura, N., Yanase, K., Kamada, M., & Ueno, M. (2020). Its been shown to disrupt glycogen synthase kinase-3, a key enzyme responsible for the development of amyloid plaques and neurofibrillary tangles associated with Alzheimers disease. Considering the promise displayed and the overall lack of investigation into its efficacy, further exploration into lithium oxybutyrate is warranted. This suggests that Lithium, at a low dosage, has a beneficial effect on behavior. Hammond, W. A. Thus, studies examining the membrane transport mechanisms of LiOr, and any connections they may have to the reported elevations in serum and brain Li+ content relative to Li2CO3, are needed.
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