is 80 mg of atorvastatin too much

Take atorvastatin exactly as directed. Abstract Atorvastatin has been shown to reduce coronary events and revascularization procedures in patients with multiple risk factors for coronary heart disease. However, the dose is usually not more than 80 mg per day. Thanks for sharing experiences and information, everybody. In AMI, high-dose potent statin therapy is associated with reduced morbidity and mortality, and current guidelines recommend high-dose potent statin therapy in patients with AMI (22). The .gov means its official. A total of 106 patients hospitalized in the coronary intensive care unit of Seluk University Faculty of Medicine Department of Cardiology between January 2015 and December 2016 with STEMI and Non-ST-elevation myocardial infarction (NSTEMI) and eligible for our study were enrolled (23). (15) reported that the chemerin level is associated with the presence and severity of CAD in patients with metabolic syndrome. Meta-analysis of comparative efficacy of increasing dose of Atorvastatin versus Rosuvastatin versus Simvastatin on lowering levels of atherogenic lipids (from VOYAGER). Previous studies showed that statins have some beneficial effects independent of the LDL reduction, which are called pleiotropic effects (34). Certainly I no longer have the side effects which to me seems to out-way the very small absolute risk reduction which Statins actually provide. In 2015, more than 8.75 million people lost their lives due to coronary artery disease (CAD), accounting for 15.5% of all deaths (1). But since my bypass I changed my diet and lifestyle then I tried stopping taking them In May 2016 as I had muscle problems and fatigue and have been in a quandary since as to their benefit. Am J Geriatr Pharmacother. In the protocol of this study, the measurements of endocan, chemerin, and galectin-3 were not pre-specified. ; Funding A.T., C.A., N.A., K.D., F.A. MeSH Adipose tissue is an active endocrine organ and regulates energy homeostasis and metabolism by communicating with liver, skeletal muscle, and brain via secreted soluble protein hormones (also called as adipokines) (11, 12). When I had my stent last year, the hospital put me on 80mg. Drug utilization patterns and cardiovascular outcomes in elderly patients newly initiated on atorvastatin or simvastatin. Baseline characteristics, as well as post-treatment changes, were compared within groups by using a paired-sample t-test or Wilcoxon signed-ranks test. Before Clipboard, Search History, and several other advanced features are temporarily unavailable. The site is secure. "put me back on 20mg statin" - if he's put you back on atorvastatin after an adverse reaction, then ask to change statin. Consult with your doctor about this issue. What Are Common Side Effects of Lipitor? So I've stopped again (cholesterol 6.2) and await a new appointment to discuss with GP. Ji Q, Lin Y, Liang Z, Yu K, Liu Y, Fang Z, et al. 2008 Jan;30(1):195-205. doi: 10.1016/j.clinthera.2008.01.003. Patients were similar between treatment groups: mostly men (62.9%), over 60 years old (68.1%), non-smokers (81.0%) taking statins for secondary prevention (56.9%). Lipitor Print Save Lipitor Generic name: atorvastatin [ a-TOR-va-sta-tin ] Dosage form: oral tablet (10 mg; 20 mg; 40 mg; 80 mg) Drug class: Statins Medically reviewed by Kaci Durbin, MD. sharing sensitive information, make sure youre on a federal Partly due to fewer people smoking, not sure we can say diets have improved as diabetes and obesity are increasing so statins may well have their place. Is 40 mg of atorvastatin too much? Krysiak et al. The .gov means its official. I too am on 80 and several in my rehab group are on the same. Eligibility criteria were as follows: age >18 years and low-density lipoprotein-cholesterol (LDL-C) >100 mg/dl, and myocardial infarction prior 12 h. Patients with cardiogenic shock; serum creatinine >2.5 mg per deciliter; current statin, fibrate, or other antilipid drug users; body mass index (BMI) >30; chronic muscle disease; contraindication to statin therapy or an unexplained creatine kinase elevation to 2.5-fold to upper normal limits; active infection or sepsis; blood transfusion within 3 months; chronic inflammatory and rheumatic diseases; malignancy; and the presence of obstructive hepatobiliary disease and cirrhosis were excluded from the study. Would you like email updates of new search results? 2021 Dec 8;12:693397. doi: 10.3389/fneur.2021.693397. Weng TC, Yang YH, Lin SJ, Tai SH. 8600 Rockville Pike Levels of LDL-C were calculated by using the Friedewald formula. Both statins have similar favorable effects on endocan, whereas rosuvastatin 40 mg/day seems to be more effective in terms of ability to decrease chemerin and galectin-3 levels. Cholesterol (and triglycerides) are fats that are made in your body. The https:// ensures that you are connecting to the Association of serum chemerin levels with the severity of coronary artery disease in patients with metabolic syndrome. STEMI is a clinical syndrome defined by typical symptoms of myocardial ischemia lasting at least 30 minutes or more with persistent electrocardiographic ST elevation and subsequent release of myocardial necrosis biomarkers. - stopping the possible cause of muscle weakness and joint pain by tapering off the Atorvastatin, and of course, have another drug to replace it. My neighbour is a prime example of statin taking over 14 years. Been on 80mg atorvasatin since ha 2014, they tried in 2106 to lower to 40mg but soon after put back to 80mg. 2016 Sep;95(39):e4906. However, to the best of our knowledge, there is no study investigating the possible role of baseline galecin-3 levels on response to statin treatment in patients with ischemic heart disease and AMI. Hubby has been on 80mg for the last 12 years following HA and stent. thank you if you knew the whole storey you would cry but thats life take care. Conclusions: Atorvastatin in daily dose of 40 mg is a safe and well tolerable medication for the treatment for dyslipidemic disorders in patients of different clinic profile and cardiovascular risk groups in common medical practice. Atorvastatin 80 mg/day reduced CRP levels to a greater extent than either simvastatin 40 mg/day or pravastatin 40 mg/day in the Atorvastatin versus Simvastatin on Atherosclerosis Progression (ASAP) (van Wissen et al 2002) and REVERSAL (Nissen et al 2004) trials, respectively. Summary Common side effects of Lipitor include: hemorrhagic stroke, arthralgia, diarrhea, and nasopharyngitis. The comparison between two doses revealed a non-significant difference (p = .118 & p = .149 respectively). he has a permanently stiff neck and has been diagnosed with muscle wasting, he has come off them now but it is too late to rebuild/repair the damage, he is 68. hi im not sure about that test ive been to ent and they did the tests on me and said i didnt have vertigo i feel better not being on statins but my cardiac consultant wants me on them thanks for your advice god bless, thank you bigleg for your advice again god bless. The value of the serum levels of TC (from 181.6435.42 mg/dL to 138.3634.08 mg/dL in the atorvastatin group, p<0.001, and from 206.3336.00 mg/dL to 143.2739.95 mg/dL in the rosuvastatin group, p<0.001, respectively), LDL-C (from 120.0827.68 mg/dL to 72.2225.09 mg/dL in the atorvastatin group, p<0.001, and from 131.6924.61 mg/dL to 69.0626.62 mg/dL in the rosuvastatin group, p<0.001, respectively) were significantly reduced within atorvastatin and rosuvastatin groups (Table 2). The aim of this audit was to examine the use, efficacy and tolerability of high intensity statin treatment (simvastatin 80 mg; atorvastatin 80 mg) in primary care. Rikitake Y, Kawashima S, Takeshita S, Yamashita T, Azumi H, Yasuhara M, et al. White HD, Chew DP. Oxidized-LDL levels showed a significant reduction in both groups (p<0.001). Some patients may need to start at 40 mg per day. Atorvastatin is used together with diet . 2]. The https:// ensures that you are connecting to the The site is secure. Atorvastatin only comes in the form of a tablet you take by mouth. I have been told that it could of been worse as my blockage was in the LAD witch is usually called the widow maker. There were no statistically significant differences between both treatment arms among the results of lipid parameters at the end of 1- month therapy except LDL-C levels. What can affect dosage Missed dose Overdose Talk with your doctor Q&A Introduction If you have high cholesterol or certain risk factors for heart disease or stroke, your doctor might suggest. Distribution of continuous variables was tested using the KolmogorovSmirnov test. Am J Ther. Clipboard, Search History, and several other advanced features are temporarily unavailable. . Told to have another blood test in 3 months to further assess. Reduction in recurrent cardiovascular events with intensive lipid-lowering statin therapy compared with moderate lipid-lowering statin therapy after acute coronary syndromes from the PROVE IT-TIMI 22 (Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction 22) trial. Many pills look alike, so keeping them in their original containers will help know the name of the drug and how to take them. Accidentally taking an extra dose of atorvastatin is unlikely to cause any serious harm. Xiaotao L, Xiaoxia Z, Yue X, Liye W. Serum chemerin levels are associated with the presence and extent of coronary artery disease. Please start keeping track of all your blood work, tests and the results. hi ive been told to try a different statin because my cardiac consultant says i have to be on a statin has the specialist-led treatment helped you ? Have you had a calorific test at the hospital? Chemerin is a novel adipokine that regulates adipogenesis and the adipocyte metabolism (12, 13). A medication error is defined as any preventable event that may cause or lead to inappropriate medication use or patient harm while the medication is in the control of the healthcare professional, patient, or consumer, according to the National Coordinating Council for Medication Error Reporting and Prevention. Mapping of the galectin-3 gene (LGALS3) to human Chromosome 14 at region 14q21-22. Federal government websites often end in .gov or .mil. Balta S, Mikhailidis DP, Demirkol S, Ozturk C, Celik T, Iyisoy A. Endocan:A novel inflammatory indicator in cardiovascular disease?Atherosclerosis 2015. However, depending on the dose, signs of an overdose on this drug can include: trouble breathing due to allergic reaction, passing out, jaundice, indicating liver damage, dark urine/muscle pain, indicating rhabdomyolysis and kidney damage and seizures. I no longer trust any Statins after years of excessive joint pain.then painkillers that damaged my heart. Admission Endocan Level may be a Useful Predictor for In-Hospital Mortality and Coronary Severity Index in Patients With ST-Segment Elevation Myocardial Infarction. The present substudy comprised 63 consecutively included patients to examine and compare the effects of atorvastatin 80 mg and rosuvastatin 40 mg on plasma levels of endocan, chemerin, and galectin-3. Types of stents (bare metal stent or drug eluting stent) and the number of revascularized vessels were also comparable among the two treatment groups (Table 1). However, it was pre-specified to include measurements of newer markers of inflammation, endothelial dysfunction, and atherosclerosis that were not well known when the protocol was finished. I know that sounds a bit trite and I have not been in your position, I'm sure there are others on here who have and can help you. DISCLAIMER: The topics and articles published on this website including text, graphics, videos info graph and other material are for informational purposes only and should not be substituted for professional medical advice. Int J Clin Pract. Standard-Dose Atorvastatin Treatment in Patients With Symptomatic Middle Cerebral Artery Atherosclerotic Stenosis: A Vessel Wall Magnetic Resonance Imaging Study. official website and that any information you provide is encrypted Effects of 12 weeks of atorvastatin therapy on myocardial fibrosis and circulating fibrosis biomarkers in statin-naive patients with hypertension with atherosclerosis. How much of that is the statin & how much is cutting out the daily breakfast Pepperoni and regular multipacks of crisps (can never eat just one packet!) Furthermore, patients on simvastatin were more likely to be failing conventional targets of lipid control, compared with patients on atorvastatin 80 mg (43.5% vs. 21.3%, p=0.006). While you're taking atorvastatin, drinking too much grapefruit juice . 2022 Jun 28;2022:2751750. doi: 10.1155/2022/2751750. 2014 AHA/ACC Guideline for the Management of Patients With Non-ST-Elevation Acute Coronary Syndromes:Executive Summary A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Raimond J, Zimonjic DB, Mignon C, Mattei MG, Popescu NC, Monsigny M, et al. According to our findings, the effect of atorvastatin 80 mg/day on chemerin levels was limited, while rosuvastatin 40 mg/day significantly reduced the serum chemerin levels at the end of 4-week therapy (Table 2). It does eventually cease when the labyrinths settle down in the inner ear canal but can be very depressing and debilitating. HHS Vulnerability Disclosure, Help Please enable it to take advantage of the complete set of features! Ah thank you for your replies, this is very comforting and helpful to me, I am due an assessment /blood test soon but feel more reassured o continue on high dose now. Evaluation of plasma chemerin levels in patients with non-dipper blood pressure patterns. This is a process of elimination if nobody can be sure whether her legs' inability to . Bookshelf (33) investigated the relationship between endocan levels and the presence and severity of CAD in patients with hypertension, and they found an independent correlation between endocan levels and the presence and severity of CAD. But iam here for my Cholesterol. Atorvastatin (Lipitor) is known as a moderate-to-high-intensity statin, meaning it lowers your cholesterol more so than many other statins. Even on only 20mg Simvastatin I find myself falling asleep whenever I sit down after four days into the course. We conducted a post hoc analysis of a subgroup of 999 patients who had a first acute myocardial infarction (MI) <2 months before randomization in a prospective, open-label, blinded end-point evaluation trial of 8,888 patients with a history of MI that compared intensive statin therapy (atorvastatin 80 mg) to standard statin therapy (simvastatin 20 to 40 mg) over approximately 5 years of follow-up. Menon P, Kocher ON, Aird WC. The ST elevation was defined as a new ST elevation at the J point in at least 2 contiguous leads 2 mm (0.2 mV) in men or 1.5 mm (0.15 mV) in women in leads V2V3 and/or 1 mm (0.1 mV) in other contiguous chest leads or the limb leads (24). Dark urine? Statins show its pleiotropic effects via various ways: anti-inflammatory, antioxidant, anti-neovascularization, and healing effects on endothelial functions (36-39). Of the 106 patients enrolled in this study, 63 (59%) subjects had a baseline plasma specimen available for the measurement of endocan, chemerin, and galectin-3. I seem fine on that dosage, so will continue. Thanks, interesting to get others views. Winter MP, Wiesbauer F, Alimohammadi A, Blessberger H, Pavo N, Schillinger M, et al. and transmitted securely. Federal government websites often end in .gov or .mil. In the LUNAR study, while the atorvastatin 80 mg provided a 42% reduction in LDL-C levels, rosuvastatin 40 mg provided a 46.8% reduction in LDL-C levels at the end of 6 weeks (29). While Atorvastatin 80 mg results in LDL reduction as 50.11 15.85 & 52.30 13.72. please ive had a triple by pass op whch failed within months had 2 stents and for over a year now ive had a problem when out walking my head is light headed/dizzy getting worse sitting down driving etc ive had all the tests at cardiac nothing found been to ent its not vertigo at neurology now they think it maybe post-ictal depression mild/moderate not sure tho ive not worked in 2 yrs can any one help me please just want some quality of life back thanks. Yes, I agree wholeheartedly with your statement but I am not convinced that statins are necessarily the answer to preventing heart attacks. A large observational study of cardiovascular outcomes associated with atorvastatin or simvastatin therapy in hypertensive patients without prior cardiovascular disease. Statin treatment of this patient was discontinued for 2 weeks, and after the normalization of liver enzymes and CK levels, statin treatment was continued again with atorvastatin 10 mg.
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